In 1857 Mangal Pandey started the  process of freedom from the British by discovering that gun cartridges were  greased with beef and pork.  This sent such a strong wave of anger through  both Hindu and Muslim sepoys that the Mutiny was born.  
           Today, India has 3 crore diabetics -  Hindus and Muslims. It is estimated that by 2025, this number will double to 6  crore.     
           Insulin is a hormone that controls  blood sugar and is needed to convert carbohydrates , sugars and starches found  in foods like bread and rice into energy.  People with type 1 and some  with type 2 diabetes mellitus, are unable to produce sufficient insulin in  their pancreas to regulate the glucose levels within their blood. These people  must inject insulin one or more times daily in order to manage their condition.  It cannot be taken by mouth as the acids in the stomach destroy it. So it is  injected by needle or spray.  
           How is this insulin made ? By killing millions of cows and pigs and  putting their insulin into the human body( In the butcher shop the cow’s  pancreas is sold as sweetbread ).  
          
            
            In  1921, Frederick Banting and Charles Best in Canada first isolated a secretion  called insulin from the pancreas of dogs. Best later extracted insulin from cow  pancreas, purified it, filtered it, then tested it on dogs . However the experiments made by Banting  on thousands of dogs were of no value to human medicine, since the dogs were  not suffering from diabetes . Banting and Best killed thousands of dogs . They  tied off the pancreas in the dogs to make it deteriorate. Then they would take  an extract of the pancreas and give it to dogs with no pancreas. This resulted  in the death of the dogs. Their experiments were criticised by the medical  establishment, including the British Medical Journal, which said the results  were ”too capricious and indefinite to carry conviction”, and “no results of  any value had been obtained by this method of treating human diabetes.”  
           Despite this, it is claimed that  Banting and Best discovered Insulin. Fredick Banting had received a Nobel prize  with J J R Macleod for isolating insulin, although Macleod admitted that they  had not discovered insulin, they had merely reproduced in the animal lab what  was already known. Banting also admitted this in "The Story of  Insulin" which he wrote in 1940. The medical historian Bliss wrote  "Banting and Best did not discover insulin…it is particularly important to  repeat that Banting's great idea, duct ligation on dogs played no essential  part in the discovery." The existence of insulin was known before Banting  and Best's activities, and the vital purification took place in a chemistry  lab.
            
           
                    The first person believed to have  successfully administered insulin was MacKenzie Wallis, a British doctor who  had learnt from his work in India  a great deal about diabetes. He rejected the use of rabbits to screen insulin  batches, instead using the test tube method, and treated the first patient  within days of the attempts by Banting and Best to treat a 14 year old boy .  
           Unfortunately because of the  preoccupation with animal testing for insulin . animal extracted insulin became  dominant .  A great deal of resources and time focussed on animal use and  extracting insulin from them. Although cow and pig insulin work, their use  often resulted in severe allergic reactions because of the simple fact that they are protein foreign to the human  body.  
           By the 1980s  the  pharmaceutical companies discovered that insulin can also be made by taking  human pancreatic cells and reproducing them in bacteria to produce human  insulin in laboratories. This insulin which is “ artificial insulin “ is now on  sale along with “ natural insulin “ which is the insulin from cows and pigs.  But most people do not know the difference leaving the choice to their doctors.  
           In fact most pharmaceutical companies  would be happy to stop animal based insulin as they say genetically engineered  insulin more closely resembles insulin made by the human pancreas. But there  are many people in the West who insist that they prefer the pancreas of cows  and pigs to their own. In fact some diabetics in Canada have gone to court for their  right to use it. Since Canadian companies El Lilly and Co and Novo Nordisk have  stopped producing animal based insulin, many people in Canada import it from countries in Asia which are still making cow and pig pancreas  insulin.While most American companies do not make animal based insulin,  European ,British and Indian companies do.
            
 
           In India , the genetically  manufactured insulin(rDNA) entered only in 1995 via Eli Lilly which also sells  the pig and cow insulin till now. The human one is called Huminsulin. Now  Novo Nordisk and Aventis Pharma also  sell  rDNA insulin in India.  Wockhardt(Wosulin) and Biocon ( Insugen) and Shreya Life Sciences Pvt Ltd (  Recosulin )  are indigenous companies selling human insulin.  
           The insulin market is estimated at  Rs 251 crore (the global insulin market is pegged  at Rs 1,500 crore) - and unfortunately the growth  rate is about  21.4 % . The human insulin market is growing but about Rs  25 crore worth of cow/pig insulin is still sold  in the country.  
           Who are the companies making cow and pig  insulin  in India  ?Cadila Pharma, Sarabhai, Glenmark Pharmaceuticals .   
            Genetically engineered insulin is replacing  porcine and bovine insulin  which is being phased out – but the speed of  the replacement depends on which insulin you demand from your doctor.  So  many of you have been injecting cow /pig blood cells  into yourselves  daily.  Will you continue to be ignorant and put your beliefs on standby  ? 
          
          
          
            
           
            
            
            
            
              
          To join the animal welfare movement contact gandhim@nic.in 
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